The focus of this Health Technology Assessment is evaluation of the clinical validity and clinical utility of wide-area transepithelial sampling biopsy with 3-dimensional (WATS3D) imaging as an adjunct to or replacement for standard forceps biopsy of the esophagus for detection of Barrett’s esophagus (BE) and esophageal dysplasia, with the goal of reducing the risk of progression to esophageal cancer.